Azilpres Plus
Rx40 mg • Tablet
Indications & Uses
Azilpres Plus is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended starting dose is 40/12.5 mg taken orally once daily. Most of the antihypertensive effect is apparent within 1 to 2 weeks. This combination may be used to provide additional blood pressure lowering for patients not adequately controlled on ARB or diuretic monotherapy treatment. Patients not controlled with azilsartan medoxomil 80 mg may have an additional systolic/diastolic clinic blood pressure reduction of 13/6 mm Hg when switched to this combination 40/12.5 mg.This combination may be used as initial therapy if a patient is likely to need multiple drugs to achieve blood pressure goals. Patients titrated to the individual components (azilsartan medoxomil and chlorthalidone) may instead receive the corresponding dose of this combination. This may be taken with or without food.
Side Effects
The following potential adverse reactions are- Fetal toxicity Hypotension in Volume- or Salt-Depleted Patients Impaired Renal Function Hypokalemia Hyperuricemia
Cautions & Contraindications
Warnings & Precautions
In patients with an activated renin-angiotensin-aldosterone system (RAAS), such as volume- and/or salt-depleted patients, Azisan Plus can cause excessive hypotension. Correct volume or salt depletion prior to administration of azilsartan and chlorthalidone. In patients with renal artery stenosis, Azisan Plus may cause renal failure. Monitor renal function in patients with renal impairment. Consider discontinuing Azisan Plus with progressive renal impairment. Heart rhythm problems (e.g., bradycardia, QT prolongation, ventricular tachycardia), liver problems, certain uncorrected mineral imbalances (low potassium/magnesium levels), severe kidney problems.
Contraindications
This is contraindicated in patients with anuria.