Pricing
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All price changes →Indications & Uses
Arofrez is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and elderly patients: The recommended dose is 2.5 mg of Letrozole taken once a day. In the adjuvant and extended adjuvant setting, treatment is continued for 5 years or until the tumor relapses, whichever happens first. In metastatic disease, treatment is continued until the tumor progresses. Elderly patients do not need a dose adjustment. Patients with liver and/or kidney impairment: No dose adjustment is needed for patients with liver impairment or kidney impairment (creatinine clearance ≥10 mL/min). However, patients with severe liver impairment (Child-Pugh score C) should be monitored closely. Children: Not applicable.
Side Effects
Common: Plot flushes, Increased level of cholesterol (hypercholesterolemia), Fatigue, Increased sweating, Pain in bones and joints (arthralgia), Skin rash, Fleadache, Dizziness, Malaise (generally feeling unwell), gastrointestinal disorders such as nausea, vomiting, indigestion, constipation, diarrhea. Increase in or loss of appetite ,Pain in muscles Thinning or wasting of your bones (osteoporosis), leading to bone fractures in some cases, Swelling of arms, hands, feet, ankles (edema), Depression, Weight increase, Flair loss, Raised blood pressure (hypertension), Abdominal pain, Dry skin, Vaginal bleeding, Palpitations, rapid heart rate, Joint stiffness (arthritis), Chest pain.Rare: Nervous disorders such as anxiety, nervousness, irritability, drowsiness, memory problems, Somnolence, insomnia, Pain or burning sensation in the hands or wrist (carpal tunnel syndrome) Impairment of sensation, especially that of touch ,Eye disorders such as blurred vision, eye irritation ,Skin disorders such as itching (urticarial). Vaginal discharge or dryness Dryness of mucous membranes, Weight decrease, Urinary tract infection, increased frequency of urination, Cough, Increased level of enzymes, yellowing of the skin and eyes, High blood levels of bilirubin (a breakdown product of red blood cells)
Cautions & Contraindications
Warnings & Precautions
In breast cancer patients with moderate hepatic dysfunction, no dosage adjustment is necessary, but caution is recommended since Letrova elimination depends mainly on intrinsic metabolic clearance. Renal impairment (calculated creatinine clearance: 20 to 50 ml/min) did not affect steady-state plasma Letrova concentration at a dose of 2.5 mg or 5 mg. Hence, no dose adjustment is necessary for such renal function impairment. It is anticipated that Letrova could be removed from blood by dialysis since it is weakly bound to plasma proteins. The potential risks and benefits to such patients should be considered carefully before prescribing Letrova. In some cases, fatigue and dizziness have been observed with the use of Letrova. Patients should therefore, be advised that their physical and/or mental abilities required for operating machinery or driving a car may be impaired.
Contraindications
Letrozole should not be used by anyone with a known or suspected hypersensitivity to letrozole, to other aromatase inhibitors, or to any of the ingredients it contains. It is not to be used during pregnancy or while breastfeeding, and it is not suitable for women who have not yet reached menopause. It should also be avoided by patients with severe liver impairment.