Apridex

Adults:

Postoperative nausea and vomiting: the recommended oral dose of aprepitant is 40 mg, taken within 3 hours before induction of anaesthesia. Chemotherapy-induced nausea and vomiting: for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, the following regimen should be used. On Day 1, aprepitant 125 mg orally, dexamethasone 12 mg orally, and a 5-HT3 antagonist (ondansetron) 24 mg given 30 minutes before the start of chemotherapy. On Day 2, aprepitant 80 mg orally and dexamethasone 8 mg orally. On Day 3, aprepitant 80 mg orally and dexamethasone 8 mg orally. On Day 4, dexamethasone 8 mg orally. Aprepitant is given orally 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3. Dexamethasone is given 30 minutes before chemotherapy on Day 1 and in the morning on Days 2 through 4. The dexamethasone dose takes drug interactions into account. For the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy, the following regimen should be used. On Day 1, aprepitant 125 mg orally, dexamethasone 12 mg orally, and a 5-HT3 antagonist (ondansetron) as one 8 mg tablet 30 minutes before chemotherapy, followed by a further 8 mg dose 8 hours later. On Day 2, aprepitant 80 mg orally and ondansetron 8 mg tablet twice a day. On Day 3, aprepitant 80 mg orally and ondansetron 8 mg tablet twice a day. Aprepitant is given orally 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3. Dexamethasone is given 30 minutes before chemotherapy on Day 1. The dexamethasone dose takes drug interactions into account. Aprepitant may be taken with or without food. No dose adjustment is needed for elderly patients.