Indications & Uses
Adrebloc is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Administer intravenously. Titrate using ventricular rate or blood pressure at ≥4 minute intervals. Supraventricular tachycardia (SVT) or noncompensatory sinus tachycardia- Optional loading dose: 500 mcg per kg infused over one minute Then 50 mcg per kg per minute for the next 4 minutes Adjust dose as needed to a maximum of 200 mcg per kg per minute Additional loading doses may be administered Perioperative tachycardia and hypertension- Loading dose: 500 mcg per kg over 1 minute for gradual control (1 mg per kg over 30 seconds for immediate control). Than 50 mcg per kg per minute for gradual control (150 mcg per kg per minute for immediate control) adjusted to a maximum of 200 (tachycardia) or 300 (hypertension) mcg per kg per minute.
Side Effects
Most common adverse reactions (incidence> 10%) are symptomatic hypotension (hyperhidrosis, dizziness) and asymptomatic hypotension.
Cautions & Contraindications
Warnings & Precautions
Risk of hypotension, bradycardia, and cardiac failure: Reduce or discontinue use Risk of exacerbating reactive airway disease Diabetes mellitus: Increases the effect of hypoglycemic agents and masks hypoglycemic tachycardia Risk of unopposed alpha-agonism and severe hypertension in untreated pheochromocytoma Risk of myocardial ischemia when abruptly discontinued in patients with coronary artery disease
Contraindications
Severe sinus bradycardia Heart block greater than first degree Sick sinus syndrome Decompensated heart failure Cardiogenic shock Coadministration of IV cardiodepressant calcium-channel antagonists (e.g. verapamil) in close proximity to Esmolol hydrochloride Pulmonary hypertension Known hypersensitivity to esmolol