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These brands contain the same active ingredient (Orlistat). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Adiponil is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Orlistat is usually taken as one 120 mg capsule with each main meal, either just before eating, with the meal, or up to an hour afterward. If a meal is skipped or contains no fat, that dose should be skipped too. Taking more than 120 mg three times a day has not been shown to add any extra benefit. Its effect on fat absorption shows up as increased fecal fat within 24 to 48 hours of dosing, and after stopping treatment, fecal fat levels usually return to normal within 48 to 72 hours. Orlistat's safety and effectiveness have been studied in clinical trials lasting as long as 4 years, and the recommended dose for adolescents is the same as for adults. Special dosage note: Orlistat's tolerability and effectiveness have not been studied in elderly patients or in those with liver or kidney impairment.
Side Effects
Common: Side effects of Orlifit are mostly related to the digestive system. Patients commonly notice oily spotting from the rectum, gas, a sudden urge to pass stool, oily or fatty stools, and stomach discomfort. Rare: Some patients may occasionally experience flu-like symptoms, anxiety, headache, or tiredness. Allergic reactions have also been reported rarely, with symptoms such as itching, skin rash, hives, swelling beneath the skin, and, in rare cases, a severe allergic reaction (anaphylaxis).
Cautions & Contraindications
Warnings & Precautions
Organic causes of obesity (e.g. hypothyroidism) should be excluded before prescribing Orlifit. Orlifit and cyclosporine should not be coadministered. Cyclosporine should be taken at least 2 hours before or after Orlifit in patients taking both drugs. Cyclosporine level should be measured and frequently monitored.In clinical trial, the decrease in body weight with Orlifit therapy was less in type II diabetic patients than in non-diabetic patients. Antidiabetic drug treatment should be closely monitored during Orlifit therapy. Because of the improvement in glycemic control, the dose of oral antidiabetics or of insulin may need to be adjusted.Patients should be advised to adhere to the dietary recommendations. The probability of occurrence of gastrointestinal side effects may increase when Orlifit is taken with a fatty meal. The daily intake of fat should be distributed between three main meals. Patients should be strongly encouraged to take a multivitamin supplement that contains fat soluble vitamins to ensure adequate nutrition because Orlifit has been shown to reduce the absorption of some fat soluble vitamins & beta-carotene. In addition, the levels of vitamin D & beta carotene may be low in obese patients compared with non-obese patients.
Contraindications
Orlistat should not be used by patients with chronic malabsorption syndrome or cholestasis, or by anyone who is hypersensitive to orlistat or to any other ingredient in the capsules.