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Other brands with the same active ingredient
These brands contain the same active ingredient (Ramipril). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Aceon
Other strengths and forms by Novo Healthcare and Pharma Ltd.
Indications & Uses
Aceon is indicated for:
Pharmacology
Ramipril is an angiotensin converting enzyme (ACE) inhibitor. After hydrolysis to ramiprilat, it blocks the conversion of angiotensin I to the vasoconstrictor substance angiotensin II. Inhibition of ACE by ramipril therefore results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and decreased aldosterone secretion. In this way, ramipril exerts its antihypertensive activity. It is also effective in the management of heart failure and in reducing the risk of stroke, myocardial infarction and death from cardiovascular events. Being long acting and well tolerated, it is suitable for long term therapy.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage of Ramipril must be adjusted according to the patient's tolerance and response. Hypertension: for the management of hypertension in adults who are not receiving a diuretic, the usual initial dose of Ramipril is 1.25 to 2.5 mg once daily. The dose is generally adjusted no more rapidly than at 2 week intervals. The usual maintenance dose in adults is 2.5 to 20 mg daily, given as a single dose or in 2 divided doses daily. If BP is not controlled with Ramipril alone, a diuretic may be added. Congestive heart failure after myocardial infarction: in this case, Ramipril therapy may be started as early as 2 days after the myocardial infarction. An initial dose of 2.5 mg twice daily is recommended, but if hypotension occurs, the dose should be reduced to 1.25 mg twice daily. Therapy is then titrated to a target dose of 5 mg twice daily. Prevention of major cardiovascular events: in this case, the recommended dose is 2.5 mg once daily for the first week of therapy and 5 mg once daily for the following 3 weeks; the dose may then be increased, as tolerated, to a maintenance dose of 10 mg once daily. Dosage in renal impairment: for patients with hypertension and renal impairment, the recommended initial dose is 1.25 mg of Ramipril once daily. Subsequent doses should be titrated according to individual tolerance and BP response, up to a maximum of 5 mg daily. For patients with heart failure and renal impairment, the recommended dose is 1.25 mg once daily. The dose may be increased to 1.25 mg twice daily and up to a maximum of 2.5 mg twice daily, depending on clinical response and tolerability.
Side Effects
Ramipril is generally well tolerated. The most commonly reported side effects are dizziness, headache, fatigue and asthenia (weakness). Less frequent side effects include symptomatic low blood pressure (hypotension), cough, nausea, vomiting, diarrhoea, rash, urticaria (hives), reduced urine output (oliguria), anxiety and amnesia, among others. Rarely, angioneurotic oedema, anaphylactic reactions and hyperkalaemia (raised blood potassium) have also been reported.
Cautions & Contraindications
Warnings & Precautions
Ramipril should be used with caution in patients with impaired kidney function, high blood potassium levels (hyperkalaemia), low blood pressure (hypotension), or impaired liver function.
Contraindications
Ramipril must not be used in patients who are hypersensitive to ramipril, to any other ACE inhibitor, or to any of the excipients in the product. It is also contraindicated in patients with a history of angioedema, and it must not be taken together with sacubitril/valsartan. Ramipril should not be started until sacubitril/valsartan has been cleared from the body, and when switching from ramipril to sacubitril/valsartan, the latter should not be started until ramipril has been cleared from the body. Ramipril is contraindicated in patients with haemodynamically relevant renal artery stenosis, whether bilateral or unilateral in a single kidney, and in patients who are hypotensive or haemodynamically unstable. It must not be combined with aliskiren-containing medicines in patients with diabetes or with moderate to severe renal impairment (creatinine clearance below 60 ml/min), nor with angiotensin II receptor antagonists (AIIRAs) in patients with diabetic nephropathy. It must not be used during pregnancy. Combining ACE inhibitors with extracorporeal treatments that bring blood into contact with negatively charged surfaces must be avoided, as this may cause severe anaphylactoid reactions. Such treatments include dialysis or haemofiltration using certain high-flux membranes (for example polyacrylonitrile) and low-density lipoprotein apheresis with dextran sulfate.
Pregnancy & Breastfeeding
Ramipril should not be used at any point during pregnancy, so pregnancy needs to be ruled out before starting this medicine. If treatment with an ACE inhibitor is truly unavoidable, the patient should not become pregnant while taking it. Anyone planning a pregnancy should switch, ahead of time, to a different treatment in place of an ACE inhibitor. If pregnancy occurs while a patient is already on Ramipril, it should be swapped for a non-ACE-inhibitor treatment as soon as possible, since continuing otherwise puts the baby at risk of harm. Ramipril is also not recommended while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
In elderly patients, a reduced starting dose of 1.25 mg Ramipril daily must be considered.
For patients with hepatic impairment, treatment must therefore be started only under close medical supervision. The maximum permitted daily dose in these patients is 2.5 mg Ramipril.
In renal impairment, where creatinine clearance is between 50 and 20 ml/min per 1.73 m2 body surface area, the starting dose is generally 1.25 mg Ramipril daily. The maximum permitted daily dose in this case is 5 mg.
A reduced starting dose of 1.25 mg Ramipril daily must also be considered in several other groups. These are patients whose fluid or salt depletion has not been fully corrected, patients with severe hypertension, and patients for whom a drop in blood pressure would be a particular risk (for example, those with relevant stenoses of the coronary vessels or of the vessels supplying the brain).
For patients already treated with a diuretic, consider stopping the diuretic for at least 2 to 3 days before starting Ramipril, or for longer, depending on how long the diuretic acts. If that isn't done, the diuretic dose should at least be reduced. The starting dose in patients previously treated with a diuretic is generally 1.25 mg Ramipril daily.
Overdose
Signs and symptoms
An overdose of Ramipril may cause excessive peripheral vasodilatation, which can lead to marked hypotension and shock. It may also cause bradycardia, electrolyte disturbances and renal failure.
Management
The first step is primary detoxification, for example gastric lavage, giving adsorbents, or giving sodium sulfate. If possible, this should be done within the first 30 minutes. If hypotension develops, α1-adrenergic agonists (e.g. norepinephrine, dopamine) or angiotensin II (angiotensinamide) must be considered, in addition to volume and salt substitution. Angiotensin II is usually available only in scattered research laboratories.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Drug Interactions
Common questions about Aceon 2.5 mg
What is Aceon 2.5 mg Tablet?
Aceon 2.5 mg Tablet is a medicine that contains Ramipril. It is made by Novo Healthcare and Pharma Ltd. It belongs to the Angiotensin-converting enzyme (ACE) inhibitors group of medicines.
What is Aceon used for?
Aceon is used for: Hypertension, Heart Failure, Myocardial Infarction, Stroke, Diabetes Mellitus.
What are the side effects of Aceon?
Ramipril is generally well tolerated. The most commonly reported side effects are dizziness, headache, fatigue and asthenia (weakness).
Can I take Aceon during pregnancy or while breastfeeding?
Ramipril should not be used at any point during pregnancy, so pregnancy needs to be ruled out before starting this medicine. If treatment with an ACE inhibitor is truly unavoidable, the patient should not become pregnant while taking it. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Aceon?
Signs and symptoms An overdose of Ramipril may cause excessive peripheral vasodilatation, which can lead to marked hypotension and shock. It may also cause bradycardia, electrolyte disturbances and renal failure. In an emergency call 999 or go to the nearest hospital emergency department.
Can I take other medicines with Aceon?
Some medicines can interact with Ramipril, for example: Vildagliptin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Aceon?
Aceon is a prescription (Rx) medicine. Take it as your doctor advises.