Ziprasidone

Adults: Administer capsules by mouth with food, and do not open, crush, or chew them. For schizophrenia: begin at 20 mg twice daily. The daily dose may be adjusted up to 80 mg twice daily, with adjustments made no more often than every 2 days. Doses up to 100 mg twice daily have been shown to be safe and effective, but the lowest effective dose should always be used. For acute treatment of manic or mixed episodes of bipolar I disorder: begin at 40 mg twice daily, increasing to 60 mg or 80 mg twice daily on the second day of treatment. Further adjustments should be guided by tolerability and response, within a range of 40 mg to 80 mg twice daily. For maintenance treatment of bipolar I disorder as an add on to lithium or valproate: continue at the same dose at which the patient was originally stabilized, within a range of 40 mg to 80 mg twice daily. For acute treatment of agitation associated with schizophrenia, given by intramuscular injection: 10 mg to 20 mg as needed, up to a maximum of 40 mg per day. A 10 mg dose may be repeated every 2 hours, and a 20 mg dose may be repeated every 4 hours.