Trastuzumab

Adults: Recommended doses and schedules for Trastuzumab are given below. It must not be given as an intravenous push or bolus, and it must not be mixed with other drugs. For adjuvant treatment of breast cancer, Trastuzumab is given according to one of the following doses and schedules for a total of 52 weeks of therapy. When given during and following paclitaxel, docetaxel, or docetaxel with carboplatin, the initial dose is 4 mg/kg as an intravenous infusion over 90 minutes, followed by 2 mg/kg as an intravenous infusion over 30 minutes weekly during chemotherapy for the first 12 weeks (paclitaxel or docetaxel) or 18 weeks (docetaxel with carboplatin). One week after the last weekly dose, Trastuzumab is given at 6 mg/kg as an intravenous infusion over 30 to 90 minutes every three weeks. When given as a single agent within three weeks after completing a multi-modality, anthracycline-based chemotherapy regimen, the initial dose is 8 mg/kg as an intravenous infusion over 90 minutes, with subsequent doses of 6 mg/kg as an intravenous infusion over 30 to 90 minutes every three weeks. Extending adjuvant treatment beyond one year is not recommended. For metastatic breast cancer, Trastuzumab is given alone or in combination with paclitaxel at an initial dose of 4 mg/kg as a 90-minute intravenous infusion, followed by subsequent once-weekly doses of 2 mg/kg as 30-minute intravenous infusions until the disease progresses. For metastatic gastric cancer, Trastuzumab is given at an initial dose of 8 mg/kg as a 90-minute intravenous infusion, followed by subsequent doses of 6 mg/kg as an intravenous infusion over 30 to 90 minutes every three weeks until the disease progresses. Or, as directed by the registered physician.