Tigecycline

ইঙ্গিত

Pneumonia Skin and Soft Tissue Infection

Tegalon IV Infusion is indicated for treating infections caused by susceptible strains of the designated microorganisms in the conditions listed below. Complicated Skin and Skin Structure Infections: including those caused by Escherichia coli, Enterococcus faecalis (vancomycin susceptible isolates only), Staphylococcus aureus (methicillin susceptible and resistant isolates), Streptococcus agalactiae, Streptococcus anginosus group (including S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes, Enterobacter cloacae, Klebsiella pneumoniae, and Bacteroides fragilis. Complicated Intra Abdominal Infections: including those caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin susceptible isolates only), Staphylococcus aureus (methicillin susceptible and resistant isolates), Streptococcus anginosus group (including S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros. Community Acquired Bacterial Pneumonia: including cases caused by Streptococcus pneumoniae (penicillin susceptible isolates), including cases with concurrent bacteremia, Haemophilus influenzae (beta lactamase negative isolates), and Legionella pneumophila.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Tigecycline, a glycylcycline, works by binding to the 30S ribosomal subunit of bacteria and blocking amino-acyl tRNA molecules from entering the A site of the ribosome. This stops protein translation, so amino acid residues cannot be added to growing peptide chains. Tigecycline carries a glycylamido group attached to the 9-position of minocycline, a substitution not found in any naturally occurring or semisynthetic tetracycline. This structural feature gives tigecycline distinct microbiologic properties: it is unaffected by the two major tetracycline resistance mechanisms, ribosomal protection and efflux, and has shown activity in vitro and in vivo against a broad range of bacterial pathogens. No cross resistance has been observed between tigecycline and other antibiotics. Tigecycline also remains active against organisms that resist other drug classes through mechanisms such as beta-lactamases (including extended spectrum beta-lactamases), target site modifications, macrolide efflux pumps, or changes to enzyme targets like gyrase and topoisomerase. In vitro studies have found no antagonism between tigecycline and other commonly used antibacterial drugs. Tigecycline is generally considered bacteriostatic.

Pregnancy & Breastfeeding

Tigecycline, a tetracycline-class antibiotic, should only be given during pregnancy if the expected benefit is judged to outweigh the possible risk to the unborn baby. It should also be used with caution in mothers who are breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Tigecycline's treatment duration should be based on how severe the infection is, where it's located, and how the patient responds clinically and bacteriologically. For complicated skin and skin structure infections or complicated intra-abdominal infections, Tigecycline is typically given for 5 to 14 days; for community-acquired bacterial pneumonia, treatment usually runs 7 to 14 days. Adults: Treatment starts with an initial dose of 100 mg, followed by 50 mg every 12 hours. Each dose should be given as an intravenous infusion over about 30 to 60 minutes. Pediatric use: Tigecycline's safety and effectiveness in pediatric patients under 18 years of age have not been established. Geriatric use: Studies did not find any unexpected overall differences in safety or effectiveness between geriatric and younger patients.

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পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.

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