ইঙ্গিত
Spirolac is used to manage fluid build-up (edema) and fluid in the abdomen (ascites) caused by cirrhosis of the liver, malignant ascites, nephrotic syndrome, congestive heart failure and primary hyperaldosteronism.
⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।
ফার্মাকোলজি
Description: Spironolactone is an aldosterone antagonist and a potassium-sparing diuretic. It works mainly by competitively binding to receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. This action increases the excretion of sodium and water while retaining potassium and magnesium.
Mode of action: Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone. They act primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule, increasing the excretion of sodium and water while sparing potassium. Through this mechanism, spironolactone functions as both a diuretic and an antihypertensive agent, and it may be used alone or together with other diuretics that act at more proximal sites in the renal tubule.
Absorption: In healthy volunteers, the mean time to reach peak plasma concentration is 2.6 hours for spironolactone and 4.3 hours for its active metabolite, canrenone.
Effect of food: Taking spironolactone with food increases its bioavailability (measured by AUC) by approximately 95.4%. Patients should therefore try to take spironolactone consistently, either always with meals or always without, rather than switching between the two.
Distribution: More than 90% of spironolactone and its metabolites are bound to plasma proteins.
Metabolism: Spironolactone undergoes rapid and extensive metabolism. Its metabolites fall into two main groups: those that lose the sulfur present in the parent molecule (such as canrenone) and those that retain it (such as TMS and HTMS). In humans, TMS and 7-α-thiospirolactone are only about a third as potent as spironolactone in reversing the effects of the synthetic mineralocorticoid fludrocortisone on urinary electrolyte composition.
Elimination & Excretion: The mean half-life of spironolactone itself is 1.4 hours. Its metabolites are longer-acting: the mean half-lives are 16.5 hours for canrenone, 13.8 hours for 7-α-(thiomethyl)spirolactone (TMS), and 15 hours for 6-β-hydroxy-7-α-(thiomethyl)spirolactone (HTMS). These metabolites are eliminated mainly in the urine, with a smaller portion excreted in bile.
Pregnancy & Breastfeeding
Pregnancy carries real risks if heart failure, cirrhosis or high blood pressure are not well controlled, and these conditions can also affect the baby. It's not known whether spironolactone affects a mother's milk supply.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
ডোজ নির্দেশিকা
⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।
পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া
পার্শ্বপ্রতিক্রিয়া
No side-effect data recorded yet.