ইঙ্গিত
Antogin ER is used to treat chronic angina. It can be combined with other heart medicines, including beta-blockers, nitrates, calcium channel blockers, anti-platelet drugs, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers. In patients with coronary artery disease who were already on maximal doses of amlodipine, it has been shown to further reduce the number of angina episodes. Because Antogin ER can prolong the QT interval, it is generally kept in reserve for patients who have not responded adequately to other antianginal medicines. It's also worth noting that its effect on angina frequency and exercise tolerance appears to be smaller in women than in men.
⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।
ফার্মাকোলজি
Ranolazine produces anti-ischemic and antianginal effects that are not dependent on reductions in heart rate or blood pressure. Its exact mechanism of action remains unknown, though at therapeutic levels it is known to inhibit the cardiac late sodium current (INa); how much this inhibition contributes to relief of angina symptoms is not clear. The QT prolongation seen on the surface electrocardiogram with ranolazine results from inhibition of IKr, which prolongs the ventricular action potential.
Absorption: peak plasma concentration (Cmax) is reached in 2 to 5 hours, and the half-life ranges from 6 to 22 hours.
Distribution: across a concentration range of 0.25 to 10 microg/ml, ranolazine is approximately 62% bound to human plasma proteins.
Metabolism and Excretion: ranolazine is metabolized mainly by CYP3A and, to a lesser extent, by CYP2D6. It undergoes rapid and extensive metabolism in the liver and intestine, so less than 5% is excreted unchanged in urine and feces. After a single oral dose of ranolazine solution, about 75% of the dose is excreted in urine and 25% in feces.
Pregnancy & Breastfeeding
Pregnancy Category C. Well-controlled studies in pregnant women, and studies looking at ranolazine's effects on the developing fetus, are lacking. For this reason, ranolazine should be used during pregnancy only if the potential benefit to the mother is felt to outweigh the potential risk to the fetus.
It is not known whether ranolazine passes into breast milk. Given the possibility of serious adverse effects in a nursing infant, a decision should be made to either stop breastfeeding or stop the medicine, weighing how important it is for the mother's treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
ডোজ নির্দেশিকা
⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।
পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া
পার্শ্বপ্রতিক্রিয়া
No side-effect data recorded yet.