Omeprazole

Adults: Dosage Oral use. For benign gastric and duodenal ulcer, the usual dose is 20 mg once daily, given for 4 weeks in duodenal ulceration and for 8 weeks in gastric ulceration; in severe or recurrent cases the dose may be increased to 40 mg daily. The maintenance dose for recurrent duodenal ulcer is 20 mg once daily, and for prevention of relapse in duodenal ulcer the dose is 10 to 20 mg daily. For NSAID associated duodenal or gastric ulcer, the dose is 20 mg once daily for 4 weeks, continued for a further 4 weeks if not fully healed; 20 mg once daily is also used as prophylaxis in patients with a history of NSAID associated duodenal or gastric ulcers. For gastro esophageal reflux disease, the dose is 20 mg once daily for 4 weeks, continued for a further 4 to 8 weeks if not fully healed; 40 mg once daily has been given for 8 weeks in gastro esophageal reflux disease that is refractory to other treatment, and the maintenance dose is 20 mg once daily. For long term management of acid reflux disease, the dose is 10 to 20 mg daily. For acid related dyspepsia, the dose is 10 to 20 mg once daily for 2 to 4 weeks. For prophylaxis of acid aspiration, 40 mg is given on the preceding evening, then a further 40 mg 2 to 6 hours before surgery. For Zollinger Ellison syndrome (ZES), the initial dose is 60 mg once daily, with a usual range of 20 to 120 mg daily; if the daily dose exceeds 80 mg, it should be given in two divided doses. For Helicobacter pylori eradication in peptic ulcer disease, omeprazole is recommended at a dose of 20 mg twice daily together with antimicrobial agents, using one of the following combinations: amoxicillin 500 mg with metronidazole 400 mg, both three times a day for one week; or clarithromycin 250 mg with metronidazole 400 mg, both twice a day for one week; or amoxicillin 1 g with clarithromycin 500 mg, both twice a day for one week. For paediatric use in severe ulcerating reflux esophagitis in children over 1 year, if body weight is 10 to 20 kg the dose is 10 to 20 mg once daily for 4 to 12 weeks, and if body weight is over 20 kg the dose is 20 to 40 mg once daily for 4 to 12 weeks. Intravenous injection. For prophylaxis of acid aspiration, omeprazole 40 mg is given slowly as an intravenous injection over about 5 minutes, one hour before surgery. For duodenal ulcer, gastric ulcer or reflux oesophagitis in patients for whom oral medication is not suitable, omeprazole 40 mg once daily by IV injection is recommended. For Zollinger Ellison syndrome (ZES), the recommended initial intravenous dose is 60 mg daily; higher daily doses may be needed and should be adjusted individually, and when the daily dose exceeds 60 mg it should be divided and given twice daily.