শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

MedBD
EN
Community data Updated 2 মাস আগে

ইঙ্গিত

Primary Hypercholesterolemia: Ezetrol co-administered with statin is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolemia who are not appropriately controlled with a statin alone. Ezetrol monotherapy ... Read morePrimary Hypercholesterolemia: Ezetrol co-administered with statin is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolemia who are not appropriately controlled with a statin alone. Ezetrol monotherapy is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolemia in whom a statin is considered inappropriate or is not tolerated.Prevention of Cardiovascular Events: Ezetrol is indicated to reduce the risk of cardiovascular events in patients with coronary heart disease (CHD) and a history of acute coronary syndrome (ACS) when added to ongoing statin therapy or initiated concomitantly with a statin.Homozygous Familial Hypercholesterolaemia (HoFH): Ezetrol co-administered with a statin, is indicated as adjunctive therapy to diet for use in patients with HoFH. Patients may also receive adjunctive treatments (e.g., LDL apheresis).Homozygous Sitosterolemia (Phytosterolemia): Ezetrol is indicated as adjunctive therapy to diet for use in patients with homozygous familial sitosterolemia.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Ezetimibe works at the brush border of the small intestine, where it blocks cholesterol absorption by acting on the sterol transporter Niemann-Pick C1-Like1 (NPC1L1). Less cholesterol then reaches the liver, hepatic cholesterol stores fall, and clearance of cholesterol from the blood increases.

Pregnancy & Breastfeeding

Pregnancy: Ezetimibe should only be used in pregnancy if it is clearly needed, as no clinical data exist on its use in pregnant women. Animal studies of ezetimibe used alone have not shown any direct or indirect harm to pregnancy, embryo-foetal development, birth, or development after birth.

Breastfeeding: Ezetimibe should not be used while breastfeeding. Studies in rats have shown that ezetimibe passes into breast milk; whether it passes into human breast milk is not known.

Fertility: No clinical data are available. Non-clinical studies have not shown any effect on fertility.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: The patient should follow a suitable lipid lowering diet and continue this diet throughout treatment with Ezetimibe. Adult Dose: The recommended dose is one Ezetimibe 10 mg tablet once daily. Ezetimibe can be taken at any time of day, with or without food. Use in the elderly: No dosage adjustment is required for elderly patients. Pediatric Use: For pediatric patients aged 10 to 17 years, no dosage adjustment is required, though clinical experience in pediatric and adolescent patients remains limited. When Ezetimibe is given together with a statin, the dosing instructions for that statin in adolescents should be consulted. For pediatric patients below age 10, Ezetimibe is not recommended, since safety and efficacy data in this age group are insufficient. Use in hepatic impairment: No dosage adjustment is required for patients with mild hepatic insufficiency (Child Pugh score 5 to 6). Treatment with Ezetimibe is not recommended for patients with moderate (Child Pugh score 7 to 9) or severe (Child Pugh score above 9) liver dysfunction. Use in renal impairment: No dosage adjustment is required for patients with renal impairment.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.

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