শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

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ইঙ্গিত

Hypertension Heart Failure Myocardial Infarction

Aldonist is used to treat hypertension (high blood pressure), and to manage congestive heart failure following an acute myocardial infarction (heart attack).

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Eplerenone is a blocker of aldosterone binding at the mineralocorticoid receptor. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone and potassium. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g. kidney) and nonepithelial (e.g. heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. Eplerenone has been shovvn to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of Eplerenone.

Pregnancy & Breastfeeding

Pregnancy: There are no adequate, well-controlled studies of Eplerenone use in pregnant women, so it should be used during pregnancy only if the expected benefit to the mother outweighs the possible risk to the unborn child.

Breastfeeding: It is not known whether Eplerenone passes into human breast milk after it is taken by mouth. Since many medicines do pass into breast milk and the possible effects on a nursing infant are not known, a decision should be made to either stop breastfeeding or stop the medicine, weighing how important it is for the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Congestive heart failure following a recent heart attack: The usual dose of Eplerenone for this condition is 50 mg once daily. Treatment is generally started at 25 mg once daily, with the dose increased to the 50 mg once-daily target within about 4 weeks, as the patient is able to tolerate it. Eplerenone can be taken with or without food. Hypertension: Eplerenone may be used on its own or together with other blood pressure lowering medicines. The usual starting dose for hypertension is 50 mg once daily. If blood pressure is not adequately controlled on 50 mg once daily, the dose may be increased to 50 mg twice daily. Doses higher than this are not advised, since they do not lower blood pressure any further than 100 mg a day and carry a greater risk of high potassium levels in the blood. Use in children: The safety and effectiveness of Eplerenone in pediatric patients have not been established. Use in the elderly: No differences in overall effectiveness or safety were seen in geriatric patients compared with younger adults.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.