শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

MedBD
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Community data Updated 2 মাস আগে

ইঙ্গিত

Tripsina is indicated for depressive illness, particularly where sedation is required, as well as for nocturnal enuresis (bedwetting) in children, prophylaxis of migraine, tension headache and chronic pain.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

The exact mechanism by which this drug works is not fully understood. Amitriptyline is thought to block the pump-like mechanism in nerve cell membranes that normally reabsorbs transmitter amines such as norepinephrine and serotonin, thereby raising their levels at the brain's synaptic clefts. These amines play an important role in regulating mood. According to the monoamine hypothesis of depression, one of the oldest theories in this field, depressive symptoms arise when the brain has insufficient transmission of serotonin (5-HT) and/or norepinephrine (NE). By counteracting this shortfall, amitriptyline may achieve its effect of easing depressive symptoms. It remains unclear whether its pain-relieving effects stem from this same mood-related activity, from a separate and less well understood pharmacological action, or from a combination of both.

Pregnancy & Breastfeeding

Pregnancy Category C. Studies show amitriptyline crosses the placenta, so it should be used in pregnancy only if the potential benefit to the mother outweighs the potential risk to the unborn baby. The drug also passes into breast milk, and nursing infants may be at risk of serious side effects as a result. Because of this, a decision needs to be made about whether to stop breastfeeding or stop the medicine, weighing how important it is for the mother's treatment.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Depression: The usual starting dose is 75 mg daily (30 to 75 mg daily for elderly patients and adolescents), taken either in divided doses or as a single dose at bedtime. The dose may be increased gradually as needed to 150 to 200 mg daily. Amitriptyline is not recommended for depression in children under 16 years of age. Nocturnal enuresis (bedwetting): Children aged 7 to 10 years: 10 to 20 mg at night. Children aged 11 to 16 years: 25 to 50 mg at night. Treatment, including gradual withdrawal, should not continue for more than 3 months. A full physical examination is required before any further course of treatment. Prevention of migraine: 100 mg daily. Tension headache: 10 to 25 mg three times daily.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.