শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

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Allopurinol

Drugs used in Gout Prescription
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ইঙ্গিত

Alurol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis). Alurol is indicated for management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity ... Read moreAlurol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis). Alurol is indicated for management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phospho ribosyltransferase. Alurol is indicated for the management of recurrent mixed calcium oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary and similar measures have failed.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Allopurinol is a xanthine oxidase inhibitor which is administered orally. It acts on purine catabolism without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and xanthine to uric acid, the end product of purine metabolism. Allopurinol is approximately 90% absorbed from the GI tract. Peak plasma levels generally occur at 1.5 hours to 4.5 hours. It has a plasma half life of about 1 to 2 hours. Approximately 20% of the ingested Allopurinol is excreted in the faeces.

Pregnancy & Breastfeeding

There isn't enough evidence to confirm Allopurinol is safe to use during human pregnancy. It should only be used in pregnancy if no safer option is available and if the underlying condition itself poses a risk to the mother or the unborn child. No information is currently available on how allopurinol or its breakdown products affect a breastfeeding baby.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Adults: Doctors usually start allopurinol at a low dose, such as 100 mg per day, to limit the chance of side effects, and increase it only if the response in serum urate levels is not satisfactory. Extra care is needed when kidney function is poor. Suggested dosage schedules are 100 to 200 mg daily for mild conditions, 300 to 600 mg daily for moderately severe conditions, and 700 to 900 mg daily for severe conditions. Children: In children under 15 years, the dose is 10 to 20 mg per kg of body weight per day, up to a maximum of 400 mg daily. Use in children is rarely needed, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome. Elderly: Without specific data to guide dosing, the lowest dose that gives a satisfactory reduction in urate should be used. Dosage in renal impairment: In severe renal insufficiency, it may be best to use less than 100 mg per day, or to give single doses of 100 mg at intervals longer than one day.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.