Adrenaline

ইঙ্গিত

Asthma

Adjunctive use in the management of cardiac arrest. It is used in cardiopulmonary resuscitation. Intracardiac puncture and intramyocardial injection of Adrinor may be effective when external cardiac compression and attempts to restore the circulation by electrical defibrillation or use of a pacemaker fail. Adrinor is a drug that leads to increased blood pressure, increased heart rate, increased air entry, increased blood glucose, stimulates cardiac activity and reduces allergic reactions by reducing the inflammatory response caused by histamine. Because of these properties, it is used for the treatment of allergic and anaphylactic reactions. Adrinor is the preferred treatment for anaphylactic shock and should be given immediately if a person begins showing severe allergic reactions. Adrinor is also used in life threatening asthma when ventilation is failing and the condition continues to worsen despite nebulizer therapy.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Epinephrine's actions closely resemble what happens when adrenergic nerves are stimulated. It acts on both alpha and beta receptor sites of sympathetic effector cells, with its most prominent effects seen at the beta receptors of the heart, vascular tissue and other smooth muscle. When given as a rapid intravenous injection, it produces a fast rise in blood pressure, mainly systolic, through three mechanisms: (1) direct stimulation of cardiac muscle, which strengthens ventricular contraction, (2) an increased heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given as a slow intravenous injection, epinephrine usually causes only a moderate rise in systolic pressure along with a fall in diastolic pressure. Although pulse pressure increases somewhat, mean blood pressure is not usually raised by much. As a result, the compensatory reflex mechanisms triggered by a marked rise in blood pressure do not oppose epinephrine's direct cardiac actions to the same extent as they do with catecholamines that act predominantly on alpha receptors.

Pregnancy & Breastfeeding

Pregnancy Category C. Adrenaline crosses the placenta and passes into breast milk. It should be used during pregnancy only if the potential benefits to the mother outweigh the possible risks to the fetus. Because it is excreted in breast milk and may cause adverse effects in the infant, Adrenaline is not recommended during breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Cardiac arrest: Given by intravenous injection, 1 mg repeated every 2 to 3 minutes as needed. Endotracheal route: 2 to 3 mg given via an endotracheal tube, repeated as needed. Intracardiac route: 0.1 to 1 mg injected directly into the atrium of the heart. Intraspinal route: the usual dose is 0.2 to 0.4 mg added to the anesthetic spinal fluid mixture, to prolong the anesthetic action by limiting absorption. Anaphylaxis, asthma or severe bronchospasm: the adult dose is 0.25 to 0.5 mg. It may be repeated at 5 minute intervals until perfusion and respiratory status normalize. When diluting the dose, 1 mg of Adrenaline should be diluted in 9 ml of Normal Saline. Children: initially 10 mcg per kg body weight, not to exceed 250 mcg. This may be repeated every 3 to 5 minutes if needed, with subsequent doses of 100 mcg per kg.

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পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.

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