Vesifen

Solif is used to relieve the symptoms of overactive bladder syndrome. These symptoms may include urge incontinence (a sudden, strong need to pass urine that leads to leakage), passing urine more often than usual, and a sense of urgency to urinate.

Because of how Solif works, it may cause anticholinergic side effects that are usually mild or moderate. How often these effects occur depends on the dose. The most commonly reported adverse reaction with Solif is dry mouth. It occurred in 11% of patients taking 5 mg once daily, in 22% of patients taking 10 mg once daily and in 4% of patients taking placebo. Dry mouth was generally mild and only occasionally led to treatment being stopped. In general, adherence to the medicine was very high (approximately 99%) and approximately 90% of patients treated with Solif completed the full 12 week study period. Gastrointestinal disorders: very common, dry mouth; common, constipation, nausea, dyspepsia, abdominal pain; uncommon, gastroesophageal reflux disease, dry throat; rare, colonic obstruction, faecal impaction; very rare, vomiting. Infections and infestations: uncommon, urinary tract infection, cystitis. Nervous system disorders: uncommon, somnolence, dysgeusia; very rare, dizziness, headache. Psychiatric disorders: very rare, hallucinations. Eye disorders: common, blurred vision; uncommon, dry eyes. General disorders and administration site conditions: uncommon, fatigue, peripheral oedema. Respiratory, thoracic and mediastinal disorders: uncommon, nasal dryness. Skin and subcutaneous tissue disorders: uncommon, dry skin; very rare, pruritus, rash, urticaria. Renal and urinary disorders: uncommon, difficulty in micturition; rare, urinary retention.