এই ওষুধে সাশ্রয় করুন
একই সক্রিয় উপাদানের অন্যান্য ব্র্যান্ড
এই ব্র্যান্ডগুলোতে একই সক্রিয় উপাদান আছে (Tucatinib). একই মাত্রা ও ধরন। বদলানোর আগে আপনার ডাক্তার বা ফার্মাসিস্টের সাথে নিশ্চিত হয়ে নিন।
ইঙ্গিত ও ব্যবহার
Tykasa 150 এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
প্রাপ্তবয়স্ক:
Recommended Dosage: The recommended dosage of Tucatinib is 300 mg taken orally twice daily in combination with trastuzumab and capecitabine until disease progression or unacceptable toxicity. Patients are advised to swallow Tucatinib tablets whole and not to chew, crush, or split prior to swallowing. Patients are advised not to ingest tablet if it is broken, cracked, or not otherwise intact. Patients are advised to take Tucatinib approximately 12 hours apart and at the same time each day with or without a meal. If the patient vomits or misses a dose of Tucatinib, Patients are advised to take the next dose at its usual scheduled time. When given in combination with Tucatinib, the recommended dosage of capecitabine is 1000 mg/m2 orally twice daily taken within 30 minutes after a meal . Tucatinib and capecitabine can be taken at the same time.Dosage Modifications for Severe Hepatic Impairment: For patients with severe hepatic impairment (Child-Pugh C), reduce the recommended dosage to 200 mg orally twice daily. Dosage Modifications for Concomitant Use with Strong CYP2C8 Inhibitors: Avoid concomitant use of strong CYP2C8 inhibitors with Tucatinib. If concomitant use with a strong CYP2C8 inhibitor cannot be avoided, reduce the recommended dosage to 100 mg orally twice daily. After discontinuation of the strong CYP2C8 inhibitor for 3 elimination half-lives, resume the Tucatinib dose that was taken prior to initiating the inhibitor.
পার্শ্বপ্রতিক্রিয়া
The following clinically significant side effects are observed: DiarrheA, Hepatotoxicity. The most common side effects in patients who received Tukanic (>20%) were diarrhea, palmar-plantar erythrodysesthesia, nausea, fatigue, hepatotoxicity, vomiting, stomatitis, decreased appetite, abdominal pain, headache, anemia, and rash.
সতর্কতা ও নিষেধাজ্ঞা
সতর্কতা ও সাবধানতা
Diarrhea: Tukanic can cause severe diarrhea including dehydration, hypotension, acute kidney injury, and death. In HER2CLIMB, 81% of patients who received Tukanic experienced diarrhea, including 12% with Grade 3 diarrhea and 0.5% with Grade 4 diarrhea. Both patients who developed Grade 4 diarrhea subsequently died, with diarrhea as a contributor to death. The median time to onset of the first episode of diarrhea was 12 days and the median time to resolution was 8 days. Diarrhea led to dose reductions of Tukanic in 6% of patients and discontinuation of Tukanic in 1% of patients. Prophylactic use of antidiarrheal treatment was not required on HER2CLIMB. If diarrhea occurs, administer antidiarrheal treatment as clinically indicated. Perform diagnostic tests as clinically indicated to exclude other causes of diarrhea. Based on the severity of the diarrhea, interrupt dose, then reduce dose or permanently discontinue Tukanic.Hepatotoxicity: Tukanic can cause severe hepatotoxicity. In HER2CLIMB, 8% of patients who received Tukanic had an ALT increase >5 x ULN, 6% had an AST increase >5 x ULN, and 1.5% had a bilirubin increase >3 x ULN (Grade >3). Hepatotoxicity led to dose reduction of Tukanic in 8% of patients and discontinuation of Tukanic in 1.5% of patients. Monitor ALT, AST, and bilirubin prior to starting Tukanic, every 3 weeks during treatment, and as clinically indicated. Based on the severity of hepatotoxicity, interrupt dose, then reduce dose or permanently discontinue Tukanic.Embryo-Fetal Toxicity: Based on findings from animal studies and its mechanism of action, Tukanic can cause fetal harm when administered to a pregnant woman. In animal reproduction studies, administration of Tukanic to pregnant rats and rabbits during organogenesis caused embryo-fetal mortality, reduced fetal weight and fetal abnormalities at maternal exposures >1.3 times the human exposure (AUC) at the recommended dose. Advise pregnant women and females of reproductive potential of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with Tukanic and for at least 1 week after the last dose. Advise male patients with female partners of reproductive potential to use effective contraception during treatment with Tukanic and for at least 1 week after the last dose. Tukanic is used in combination with trastuzumab and capecitabine.