Orbizolam

Adults:

Treatment should begin with 0.25 to 0.5 mg three times daily. Depending on the response, the dose may be increased at intervals of 3 to 4 days, in increments of no more than 1 mg per day. The maximum dose should not exceed 4 mg per day. Occasionally, patients with panic disorder may need as much as 10 mg a day to achieve a successful response; in these cases, periodic reassessment and consideration of dosage adjustment are required. Dosage should be individualised to achieve the maximum beneficial effect with the lowest possible dose. If side effects occur at the starting dose, the dose may be lowered. When discontinuing therapy, the dosage should be reduced gradually by no more than 0.5 mg every three days. In elderly patients, or in patients with advanced liver disease, the usual starting dose is 0.25 mg two or three times daily, which may be gradually increased if needed and tolerated. Patients who are on multiple-dose regimens of Alprazolam 0.25 mg or 0.5 mg should take Alprazolam 1 mg once daily, preferably in the morning. The tablets should be swallowed whole; they should not be chewed, crushed, or broken.