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Adults:

Adult: The dose of Clonidine Hydrochloride must be adjusted according to the patient's individual blood pressure response. Initial dose: 0.1 mg twice a day, taken in the morning and at bedtime. Elderly patients may benefit from a lower initial dose. Maintenance dose: further increments of 0.1 mg per day may be made at weekly intervals if necessary, until the desired result is achieved. The therapeutic dose most commonly employed has ranged from 0.2 mg to 0.6 mg per day, given in divided doses. In renal impairment, the dose of Clonidine Hydrochloride must be adjusted according to the degree of impairment, and the patient should be monitored carefully. For attention deficit hyperactivity disorder, Clonidine IR 5 mcg/kg/day or Clonidine ER 0.1 mg/day may be given for 8 weeks. For menopausal flushing, 0.1 mg to 0.4 mg daily may be given. For alcohol withdrawal, 0.3 to 0.6 mg may be given every 6 hours, or as directed by the physician. Use in children and adolescents: safety and effectiveness in pediatric patients have not been established in adequate and well controlled trials.