মূল্য
দামগুলো আনুমানিক MRP এবং ফার্মেসিভেদে ভিন্ন হতে পারে। সর্বশেষ নথিভুক্ত দামের সাথে তুলনা করে ট্রেন্ড দেখানো হয়।
সব দামের পরিবর্তন →ইঙ্গিত ও ব্যবহার
Linzela এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
প্রাপ্তবয়স্ক:
Irritable Bowel Syndrome with Constipation (IBS-C): The recommended dosage of Linaclotide is 290 mcg capsule orally once daily.Chronic Idiopathic Constipation (CIC): The recommended dosage of Linaclotide is 145 mcg capsules orally once daily. A dosage of 72 mcg capsule once daily may be used based on individual presentation or tolerability.
পার্শ্বপ্রতিক্রিয়া
Adverse reaction: Diarrhea, Abdominal pain, Flatulence, URI, Headache, Viral gastroenteritis, Sinusitis, Abdominal distension, Severe diarrhea, Dyspepsia, Fecal incontinence, GERD, Vomiting, Fatigue.Side effects: Diarrhea, Stomach/Abdominal Pain or Discomfort, Gas, Bloating, Heartburn, Vomiting, Headache, Cold Symptoms Such As Stuffy, Nose Sneezing Or Sinus Pain, Swelling, or A Feeling of Fullness or Pressure in the Abdomen (Distention).
সতর্কতা ও নিষেধাজ্ঞা
সতর্কতা ও সাবধানতা
Risk of Serious Dehydration in Pediatric Patients: Linzela is contraindicated in patients less than 6 years of age. The safety and effectiveness of Linzela in patients less than 18 years of age have not been established. In neonatal mice (human age equivalent of approximately 0 to 28 days), Linzela increased fluid secretion as a consequence of GC-C agonism resulting in mortality within the first 24 hours due to dehydration. Due to increased intestinal expression of GC-C, patients less than 6 years of age may be more likely than patients 6 years of age and older to develop severe diarrhea and its potentially serious consequences.Avoid use of Linzela in pediatric patients 6 years to less than 18 years of age. Although there were no deaths in older juvenile mice, given the deaths in young juvenile mice and the lack of clinical safety and efficacy data in pediatric patients, avoid the use of Linzela in pediatric patients 6 years to less than 18 years of age.Diarrhea: It was the most common adverse reaction of Linzela-treated patients in the pooled IBS-C and CIC double-blind placebo-controlled trials. The incidence of diarrhea was similar between the IBS-C and CIC populations. Severe diarrhea was reported in 2% of 145 meg and 290 meg Linzela-treated patients, and in <1% of 72 meg Linzela-treated CIC patients.In post-marketing experience, severe diarrhea associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia) requiring hospitalization or intravenous fluid administration have been reported in patients treated with Linzela. If severe diarrhea occurs, suspend dosing and rehydrate the patient.
নিষেধাজ্ঞা
Linaclotide is contraindicated in: Patients less than 6 years of age due to the risk of serious dehydration Patients with known or suspected mechanical gastrointestinal obstruction