Lefalin

প্রাপ্তবয়স্ক:

Dosage of Lefamulin in Adult CABP Patients: Lefamulin 150 mg injection every 12 hours by intravenous infusion over 60 minutes for 5 to 7 days (With the option to switch to Lefamulin Tablets 600 mg every 12 hours to complete the treatment course). Lefamulin tablet 600 mg orally every 12 hours for 5 days. For patients with severe hepatic impairment, dosage adjustment is required.Dosage Adjustment for Patients with Hepatic Impairment- Lefamulin Injection: Reduce the dosage of Lefamulin Injection to 150 mg infused intravenously over 60 minutes every 24 hours for patients with severe hepatic impairment. No dosage adjustment of Lefamulin Injection is needed for patients with mild or moderate hepatic impairment. Lefamulin Tablets: Lefamulin Tablets have not been studied in and are not recommended for patients with moderate or severe hepatic impairment. No dosage adjustment of Lefamulin Tablets is needed for patients with mild hepatic impairment. Important Administration instruction- Lefamulin Injection: Administer Lefamulin Injection by intravenous infusion over 60 minutes. Must dilute in a 250 ml solution of citrate buffered 0.9% sodium chloride for injection supplied with Lefamulin Injection before use. Lefamulin Tablets: Take Lefamulin Tablets at least 1 hour before a meal or 2 hours after a meal. Do not crush or divide Lefamulin Tablet. Missed Dose: If a dose is missed, the patient should take the dose as soon as possible and anytime up to 8 hours prior to the next scheduled dose. If less than 8 hours remain before the next scheduled dose, do not take the missed dose, and resume dosing at the next scheduled dose. Preparation of Lefamulin Injection for Intravenous Infusion- Dilute the entire 15 ml vial of Lefamulin Injection into the diluent bottle supplied with Lefamulin injection that contains 250 ml citrate buffered 0.9% sodium chloride solution. Use aseptic technique when adding Lefamulin Injection into the diluent bottle. Mix thoroughly. Use the diluent bottle only if the solution is clear and the container is undamaged. Do not use the diluent bottle in series connections. Do not add other additives to the diluent bottle because their compatibilities with Lefamulin Injection have not been established.