ইঙ্গিত ও ব্যবহার
Bortezomib Ever Pharma এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
প্রাপ্তবয়স্ক:
The recommended dose of Bortezomib is 1.3 mg/m2/dose administered as a 3 to 5 second bolus intravenous and subcutaneous injection twice weekly for 2 weeks (Days 1, 4, 8, and 11) followed by a 10-day rest period (Days 12-21). For extended therapy of more than 8 cycles, Bortezomib may be administered on the standard schedule or on a maintenance schedule of once weekly for 4 weeks (Days 1, 8, 15, and 22) followed by a 13-day rest period (Days 23 to 35).Bortezomib retreatment may be considered for patients with multiple myeloma who has previously responded to treatment with Bortezomib and who has relapsed at least 6 months after completing prior Bortezomib treatment. Treatment may be started at the last tolerated dose. Bortezomib is for intravenous or subcutaneous use only. Bortezomib should not be administered by any other route.
পার্শ্বপ্রতিক্রিয়া
The following adverse reactions can be occurred during Bortezomib Ever Pharma Ever Pharma therapy: Peripheral Neuropathy, Hypotension, Cardiac Toxicity, Pulmonary Toxicity, Posterior Reversible Encephalopathy Syndrome (PRES), Gastrointestinal Toxicity, Thrombocytopenia /Neutropenia,Tumor Lysis Syndrome, Hepatic Toxicity.
সতর্কতা ও নিষেধাজ্ঞা
সতর্কতা ও সাবধানতা
Bortezomib Ever Pharma Ever Pharma should be administered under the supervision of a physician experienced in the use of antineoplastic therapy.Peripheral Neuropathy: Bortezomib Ever Pharma Ever Pharma treatment causes a peripheral neuropathy that is predominantly sensory, although cases of motor neuropathy have also been reported. Patients with preexisting symptoms (numbness, pain or a burning feeling in the feet or hands) and/or signs of peripheral neuropathy may experience worsening peripheral neuropathy (including > Grade 3) during treatment with Bortezomib Ever Pharma Ever Pharma. Patients should be monitored for symptoms of neuropathy, such as a burning sensation, hyperesthesia, hypoesthesia, paresthesia, discomfort or neuropathic pain. Patients experiencing new or worsening peripheral neuropathy may require changes in thedose and schedule of Bortezomib Ever Pharma Ever Pharma. Starting Bortezomib Ever Pharma Ever Pharma subcutaneously may be considered for patients with pre-existing or at high risk of peripheral neuropathy.The long-term outcome of peripheral neuropathy has not been studied in mantle cell lymphoma.Hypotension: Caution should be used when treating patients with a history of syncope, patients receiving medications known to be associated with hypotension, and patients who are dehydrated. Management of orthostatic/postural hypotension may include adjustment of antihypertensive medications, hydration, and administration of mineralocorticoids and/or sympathomimetics.Cardiac Disorders: The acute development or exacerbation of congestive heart failure has been seen in patients with risk factors for, or existing heart disease. Such patients should be closely monitored. In clinical studies, isolated cases of QT-interval prolongation have been observed; causality has not been established.Gastrointestinal Adverse Events: Bortezomib Ever Pharma Ever Pharma treatment can cause nausea, diarrhea, constipation, and vomiting with sometimes requiring use of antiemetic and antidiarrheal medications. Fluid and electrolyte replacement should be administered to prevent dehydration.Pulmonary Toxicity: Acute Respiratory Distress Syndrome (ARDS) and acute diffuse infiltrative pulmonary disease of unknown etiology such as pneumonitis, interstitial pneumonia, and lung infiltration have occurred in patients receiving Bortezomib Ever Pharma Ever Pharma. Some of these events have been fatal. There have been reports of pulmonary hypertension associated with Bortezomib Ever Pharma Ever Pharma administration in the absence of left heart failure or significant pulmonary disease. In the event of new or worsening cardiopulmonary symptoms, consider interrupting Bortezomib Ever Pharma Ever Pharma until a prompt and comprehensive diagnostic evaluation is conducted.Thrombocytopenia: Bortezomib Ever Pharma Ever Pharma is associated with thrombocytopenia and neutropenia that follow a cyclical pattern with nadirs occurring following the last dose of each cycle and typically recovering prior to initiation of the subsequent cycle. The cyclical pattern of platelet and neutrophil decreases and recovery remain consistent in the studies of multiple myeloma and mantle cell lymphoma, with no evidence of cumulative thrombocytopenia or neutropenia in the treatment regimens studied. Monitor complete blood counts (CBC) frequently during treatment with Bortezomib Ever Pharma Ever Pharma. Measure platelet counts prior to each dose of Bortezomib Ever Pharma Ever Pharma. Adjust dose/schedule for thrombocytopenia. There have been reports of gastrointestinal and intracerebral hemorrhage in association with Bortezomib Ever Pharma Ever Pharma. Transfusions may be considered.Tumor Lysis Syndrome: Tumor lysis syndrome has been reported with Bortezomib Ever Pharma Ever Pharma therapy. Patients at risk of tumor lysis syndrome are those with high tumor burden prior to treatment. Monitor patients closely and take appropriate precautions.Hepatic Toxicity: Cases of acute liver failure have been reported in patients receiving multiple concomitant medications and with serious underlying medical conditions. Other reported hepatic reactions include hepatitis, increases in liver enzymes, and hyperbilirubinemia. Interrupt Bortezomib Ever Pharma Ever Pharma therapy to assess reversibility. There is limited re-challenge information in these patients.
নিষেধাজ্ঞা
Bortezomib is contraindicated in patients with hypersensitivity to Bortezomib, boron or mannitol. Reactions have included anaphylactic reactions. Bortezomib is contraindicated for intrathecal administration. Fatal events have occurred with intrathecal administration of Bortezomib.