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Same active ingredient — pay up to 30% less
These brands contain the same active ingredient (Agomelatine). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
ইঙ্গিত ও ব্যবহার
Agotin এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
The effective dose of agomelatine is 25 mg per day given once at bed time for two weeks and can be increased to 50 mg per day in patients with inadequate response. Night time dosing is recommended because agomelatine improves the quality of sleep without day time sedation. For oral administration with or without food. Most adult patients should take a dosage of 25 mg (one tablet) daily. It is usually taking prior to bed time. If no improvement is noticed after two weeks, the dosage can be increased to 50 mg (two tablets) daily.Children under 18 years: Should be given only on medical advice. Use in children and adolescents: Agomelatine is not recommended in the treatment of depression in patients <18 years since safety and efficacy of agomelatine have not been established in this age group. In clinical trials among children and adolescents treated with other antidepressants, suicide-related behavior (suicide attempt and suicidal thoughts), and hostility (predominantly aggression, oppositional behavior and anger) were more frequently observed compared to those treated with placebo.Use in the elderly: The efficacy and safety of agomelatine (25 to 50 mg/day) have been established in elderly patients with MDD (aged <75 years). As efficacy has not been established in every elder patients aged >75 years agomelatine should not be used in this patient group.
পার্শ্বপ্রতিক্রিয়া
The side effects most often reported in clinical trials of Agorest are headache, nausea and diarrhoea. Agomelatine can raise liver enzyme levels, so liver enzymes should be checked before treatment begins and then every 6 weeks during treatment. It must not be used in patients with hepatic impairment. A meta-analysis of treatment-emergent sexual dysfunction with antidepressants found no significant difference between agomelatine and placebo.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Use caution before starting treatment, and monitor all patients closely throughout the treatment period, especially if risk factors for liver injury are present or if the patient is taking other medicines associated with a risk of liver injury. Baseline liver function tests should be carried out in all patients, and treatment should not be started in patients whose baseline ALT and/or AST levels are more than 3 times the upper limit of normal. Agorest should be used with caution in elderly patients (75 years and older), as clinical data in this group are lacking. Agorest should not be used to treat major depressive episodes in elderly patients with dementia, since its safety and efficacy have not been established in these patients. Agorest is not recommended for the treatment of depression in patients under 18 years of age. Agorest should be used with caution in patients with a history of bipolar disorder, mania or hypomania.
নিষেধাজ্ঞা
Agomelatine must not be used in people who are hypersensitive to the active substances or to any of the excipients. It is also contraindicated in hepatic impairment (i.e. cirrhosis or active liver disease), or when transaminases exceed 3 times the upper limit of normal. It should not be taken together with potent CYPIA2 inhibitors (eg. Fluvoxamine, ciprofloxacin).